NEWS
Glance at International Association of Oral Pathologists
Willie van Heerden (South Africa) hands over the reins to Takashi Takata (Japan) as the new President of the IAOP for 2012-2014
President Elect: Michael Aldred (Australasia)
International Association of Oral Pathologists - Councillors (2012-2014)
Africa: Sonja Boy
Asia : Dr. K Ranganathan
Australasia: Norman Firth
Europe: Kristiina Heikenheimo
Latin America & Caribbean: Dr. Marcio Lopes
North America: Michael Rohrer
Source : IAOP News letter
Evidence-Based Women's Oral Health
Leslie R. Halpern, MD, DDS, PhD, MPH, and Linda M. Kaste, DDS, MS, PhD, Guest Editors
"Another issue on women's health?" you might ask. You are right; Dental Clinics of North America (DCNA) has previously provided the platform for dissemination of information on women and oral health. "Has much changed?" you might further ask. It has been more than a decade since the full issue "Women’s Oral Health" in July 2001, and in that time, yes, a lot has changed.
Certainly our understanding of women's health has changed, but there has been an even deeper change in our expectations as clinicians. These days, we clinicians demand increased depth and veracity of the information forming the foundations from which we work, for making our decisions evidence based. Not only have our expectations changed, the contexts in which we are working have changed. As we further integrate into comprehensive health care for our patients, it behooves us to be on a level playing field with our other health care colleagues. Also, we anticipate that our patients and communities have different expectations of us.
Dental Clinics of North America
Source : http://dental.theclinics.com/
Certainly our understanding of women's health has changed, but there has been an even deeper change in our expectations as clinicians. These days, we clinicians demand increased depth and veracity of the information forming the foundations from which we work, for making our decisions evidence based. Not only have our expectations changed, the contexts in which we are working have changed. As we further integrate into comprehensive health care for our patients, it behooves us to be on a level playing field with our other health care colleagues. Also, we anticipate that our patients and communities have different expectations of us.
Dental Clinics of North America
Source : http://dental.theclinics.com/
El Cigaret – Tips & Tricks on Using :
May 14, 2013
There’s a brand-new invention that everybody who smokes should know about about. It’s called the ecigarette, also referred to as a electric cigarette or el cigaret, in fact it is changing the legal landscape for smokers around the globe.
The branded E-cigarette offers to effectively emulate the experience of smoking an authentic cigarette, without the in the health or legal issues associated with common cigarettes.
Whilst E-cigarettes look, feel and taste comparable to conventional cigarettes, they operate very differently. The thing is, electronic cigarettes tend not to actually burn any tobacco, but instead, when you inhale from an e-cigarette, you activate a “flow censor” which releases a water vapor containing nicotine, propylene glycol, plus a scent that simulates the flavor of tobacco. Which basically means that e-cigarettes allow you to get your nicotine fix while keeping away from all of the cancer agents within standard cigarettes for example tar, glue, numerous additives, and hydrocarbons.
And also much healthier than standard cigarettes, and maybe most importantly of most, is the fact that e-cigarettes are completely legal. Because Electric cigarettes tend not to involve tobacco, you can legally light up them anywhere that traditional cigarettes are prohibited including bars, restaurants, the task place, even on airplanes. Furthermore, e-cigarettes permit you to smoke without any fears of causing harm on others as a result of nasty carbon monoxide smoke.
The refillable cartridges are available in numerous flavors along with nicotine strengths. You will get regular, menthol, even apple and strawberry flavored cartridges and nicotine strengths can be found in full, medium, light, and none. While e cigarettes are basically a “smoking alternative” instead of a quitting smoking device, the plethora of nicotine strengths offers some obvious potential as an assisted in the ones attempts to stop smoking cigarettes and looks like it’s proving popular within that market.
The nice thing about electronic cigarettes as apposed to say, nicotine patches, is e-cigarettes make the same tactile experience and oral fixation that smokers desire, while gratifying ones tobacco cravings as well. When you have a drag from n electric cigarette you really notice the your lungs fill having a warm tobacco flavored smoke and when you exhale the smoke billows through your lungs exactly like regular smoking, however, as stated, that smoke is truly a healthier water vapor that quickly evaporates and thus doesn’t offend anyone inside the immediate vicinity.
While electric cigarettes have been about for a while in a variety of incarnations, it is often recent advances in the technology and also rising limitations against smoking which may have propelled the e-cigarette in a new found popularity. Should you be interested in a much better substitute for smoking, or if you only desire to have the freedom to smoke as much as you would like, an e cigaret could be the solution you’ve been searching for.
source: www.oralpath.org
Save Money With Greensmoke Coupon Codes :
May 14, 2013
Green Smoke electric powered smokes are also called vapor cigs and are preferred all over the world as a most suitable substitute for normal cigarettes. They come in a unique two portion style which includes a high quality battery that is rechargeable and a cartomizer or a pre-filled disposable cartridge. This is for sale in a wide range of flavors based on your choice. Green Smoke Coupon codes can be found online.There are even different nicotine levels to select from. Each cartomizer is equal to about 7.5 mg of traditional cigarettes. Green Smoke e-cigarettes employ a firm, steel cover design that feels very comfortable in the hand if they are smoked.
There are several advantages of using e-cigarettes as opposed to traditional one. Green Smoke supplies a healthy alternative given it does not contain any carcinogens along with other harmful substances that can cause life threatening diseases like lung cancer and emphysema. It doesn’t have any ash, fire or disconcerting cigarette that can harm non-smokers. Whatever you get is a safe vapor that you can literally use anywhere. People who are trying to kick the smoking are known to do so using e-cigarettes such as Green Smoke.
Exclusive Cartomizer Concept
If we talk about the word cartomizer we reference the terms cartridge and atomizer. The cartridge basically could be the receptacle for your smoking liquid while the atomizer is the part that helps turn the liquid right into a smooth, flavorful aromatic vapor. When e-cigarettes were first introduced the cartridge and atomizer components were separate parts have a tendency to malfunctioned due to clogging. Green Smoke was one of the first e-cigarette manufacturers that utilized the main one piece cartomizer design which includes since get to be the gold standard inside the e-cigarette industry. The FlavorMax cartomizer utilized by Green Smoke greatly improved the quality and lifespan of the cartomizer. Users can engage in about three hundred and sixty puffs per cartomizer. Since the cartridge and atomizer are integrated collectively, it is pretty convenient for users in working order as they do not want to do any refills; just discard and pop a fresh one in place and they’re good to go. There won’t be any more spillages to concern yourself with with this convenient design feature.
Wide Selection of Flavors
Green Smoke offers customers seven exclusive flavors to choose from. All of these are available in the handy FlavorMax cartomizer, which ensures convenience while offering the best quality vapors within the e-cigarette community. If you like the very distinctive taste of tobacco then you can certainly opt for the Absolute Tobacco flavor, that includes a sweet, smooth and lightweight feel to it. If you are feeling a bit adventurous or just prefer the bold and powerful flavor of classic cigarettes then you can certainly try Red Label Tobacco flavor. It’s that Virginia tobacco taste proven to traditional smokers. For smokers they like the combination of Burley, Oriental and Virginia tastes, check out the Tobacco Gold flavor usually available to the most exquisite cigars. Anyone can feel free to enjoy the best tobacco flavors in a e-cigarette setting. Purchase your Greensmoke Coupon here
Source : www.oralpath.org
The branded E-cigarette offers to effectively emulate the experience of smoking an authentic cigarette, without the in the health or legal issues associated with common cigarettes.
Whilst E-cigarettes look, feel and taste comparable to conventional cigarettes, they operate very differently. The thing is, electronic cigarettes tend not to actually burn any tobacco, but instead, when you inhale from an e-cigarette, you activate a “flow censor” which releases a water vapor containing nicotine, propylene glycol, plus a scent that simulates the flavor of tobacco. Which basically means that e-cigarettes allow you to get your nicotine fix while keeping away from all of the cancer agents within standard cigarettes for example tar, glue, numerous additives, and hydrocarbons.
And also much healthier than standard cigarettes, and maybe most importantly of most, is the fact that e-cigarettes are completely legal. Because Electric cigarettes tend not to involve tobacco, you can legally light up them anywhere that traditional cigarettes are prohibited including bars, restaurants, the task place, even on airplanes. Furthermore, e-cigarettes permit you to smoke without any fears of causing harm on others as a result of nasty carbon monoxide smoke.
The refillable cartridges are available in numerous flavors along with nicotine strengths. You will get regular, menthol, even apple and strawberry flavored cartridges and nicotine strengths can be found in full, medium, light, and none. While e cigarettes are basically a “smoking alternative” instead of a quitting smoking device, the plethora of nicotine strengths offers some obvious potential as an assisted in the ones attempts to stop smoking cigarettes and looks like it’s proving popular within that market.
The nice thing about electronic cigarettes as apposed to say, nicotine patches, is e-cigarettes make the same tactile experience and oral fixation that smokers desire, while gratifying ones tobacco cravings as well. When you have a drag from n electric cigarette you really notice the your lungs fill having a warm tobacco flavored smoke and when you exhale the smoke billows through your lungs exactly like regular smoking, however, as stated, that smoke is truly a healthier water vapor that quickly evaporates and thus doesn’t offend anyone inside the immediate vicinity.
While electric cigarettes have been about for a while in a variety of incarnations, it is often recent advances in the technology and also rising limitations against smoking which may have propelled the e-cigarette in a new found popularity. Should you be interested in a much better substitute for smoking, or if you only desire to have the freedom to smoke as much as you would like, an e cigaret could be the solution you’ve been searching for.
source: www.oralpath.org
Save Money With Greensmoke Coupon Codes :
May 14, 2013
Green Smoke electric powered smokes are also called vapor cigs and are preferred all over the world as a most suitable substitute for normal cigarettes. They come in a unique two portion style which includes a high quality battery that is rechargeable and a cartomizer or a pre-filled disposable cartridge. This is for sale in a wide range of flavors based on your choice. Green Smoke Coupon codes can be found online.There are even different nicotine levels to select from. Each cartomizer is equal to about 7.5 mg of traditional cigarettes. Green Smoke e-cigarettes employ a firm, steel cover design that feels very comfortable in the hand if they are smoked.
There are several advantages of using e-cigarettes as opposed to traditional one. Green Smoke supplies a healthy alternative given it does not contain any carcinogens along with other harmful substances that can cause life threatening diseases like lung cancer and emphysema. It doesn’t have any ash, fire or disconcerting cigarette that can harm non-smokers. Whatever you get is a safe vapor that you can literally use anywhere. People who are trying to kick the smoking are known to do so using e-cigarettes such as Green Smoke.
Exclusive Cartomizer Concept
If we talk about the word cartomizer we reference the terms cartridge and atomizer. The cartridge basically could be the receptacle for your smoking liquid while the atomizer is the part that helps turn the liquid right into a smooth, flavorful aromatic vapor. When e-cigarettes were first introduced the cartridge and atomizer components were separate parts have a tendency to malfunctioned due to clogging. Green Smoke was one of the first e-cigarette manufacturers that utilized the main one piece cartomizer design which includes since get to be the gold standard inside the e-cigarette industry. The FlavorMax cartomizer utilized by Green Smoke greatly improved the quality and lifespan of the cartomizer. Users can engage in about three hundred and sixty puffs per cartomizer. Since the cartridge and atomizer are integrated collectively, it is pretty convenient for users in working order as they do not want to do any refills; just discard and pop a fresh one in place and they’re good to go. There won’t be any more spillages to concern yourself with with this convenient design feature.
Wide Selection of Flavors
Green Smoke offers customers seven exclusive flavors to choose from. All of these are available in the handy FlavorMax cartomizer, which ensures convenience while offering the best quality vapors within the e-cigarette community. If you like the very distinctive taste of tobacco then you can certainly opt for the Absolute Tobacco flavor, that includes a sweet, smooth and lightweight feel to it. If you are feeling a bit adventurous or just prefer the bold and powerful flavor of classic cigarettes then you can certainly try Red Label Tobacco flavor. It’s that Virginia tobacco taste proven to traditional smokers. For smokers they like the combination of Burley, Oriental and Virginia tastes, check out the Tobacco Gold flavor usually available to the most exquisite cigars. Anyone can feel free to enjoy the best tobacco flavors in a e-cigarette setting. Purchase your Greensmoke Coupon here
Source : www.oralpath.org
DNA REPAIR ENZYME OGG 1- (8- OXOGUANINE DNA GLYCOSYLASE 1) :
Dr.Radhika M Bavle*, Dr.Sreelatha S Hosthor**, Dr.Shalini S***
*Hon Editor-in-Chief JOMFP, ** Associate Editor – JOMFP, *** Post graduate student, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bangalore
DNA is the KEY OF LIFE. Any sustained damage to the DNA invariably presents as a disease or pathology. This invites a need for DNA repair, without which the sustainability of life becomes a big question mark. Hence, comes the real saviours - THE MASTER REGULATORS: OGG1. 8-Oxoguanine glycosylase also known as OGG1 is a DNA glycosylase enzyme that, in humans, is encoded by the OGG1 gene. It is a DNA repair enzyme involved in base excision repair. It is found in bacterial, archaeal and eukaryotic species. Also known as HMMH, MUTM, OGH1, HOGG1. Cytogenetic Location: The OGG1 gene is located on the short (p) arm of chromosome 3 at position 26.2. (3p26.2) More precisely, the OGG1 gene is located from base pair 9,791,627 to base pair 9,808,352 on chromosome 3. Function: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. OGG1 is a bifunctional glycosylase, as it is able to cleave the glycosidic bond of the mutagenic lesion and also cause a strand break in the DNA backbone. The action of this enzyme includes lyase activity for chain cleavage. Significance: The majority of DNA damage is caused by ubiquitous reactive oxygen species(ROS). ROS are chemically very active molecules created as byproducts of respiration. When DNA meets reactive oxygen species, one of the most common reactions is the transformation of the DNA base guanine into a molecule called 8-oxoguanine, which can produce mutations in genes. To protect the integrity of the genetic code, cells remove 8-oxoguanine from their DNA with a repair enzyme called OGG1. OGG1 does its job by attaching to a damaged base, cutting it free from the DNA molecule, and then releasing it. Boldogh and his collaborators proposed the hypothesis that instead of the accumulation of damaged guanine in DNA causing ill effects, what is significant, is the release of a DNA-repair byproduct that somehow activates processes that shorten the lifespan of cells. In experimenting this ,they found their key byproduct was being produced just after this repair process was completed. Analyzing test-tube, cell-culture and mouse experimental data, they realized that immediately after being released by OGG1, 8-oxoguanine reunites with the repair enzyme, attaching at a bonding site different from the one used previously. And the resulting 8-oxoguanine-OGG1 complex, they found, has the ability to activate the powerful Ras signaling pathways, some of the most important biochemical networks in the cell. Ras family proteins are involved in almost every cell function like metabolism, activation of genes, growth signals, inflammation signals, apoptosis. Because it activates Ras pathway, the release of 8-oxoguanine in DNA base repair could be a master regulator of many basic processes. Learning to control this "Master regulator," could result in profound consequences for biomedical science and human health. The ability to regulate 8-oxoguanine excision may give us the ability to prevent the inflammation that is key to a number of chronic diseases — arthritis, atherosclerosis, Alzheimer's and others. It is believed that it may even enable us to extend lifespan, or at least healthy lifespan, which would be a very big achievement. Possibilities like that make us believe that this discovery is going to be very significant.Advancement : It has been found that OGG1 tagging has been successful by researchers in Harvard University .
Dr.Radhika M Bavle*, Dr.Sreelatha S Hosthor**, Dr.Shalini S***
*Hon Editor-in-Chief JOMFP, ** Associate Editor – JOMFP, *** Post graduate student, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bangalore
DNA is the KEY OF LIFE. Any sustained damage to the DNA invariably presents as a disease or pathology. This invites a need for DNA repair, without which the sustainability of life becomes a big question mark. Hence, comes the real saviours - THE MASTER REGULATORS: OGG1. 8-Oxoguanine glycosylase also known as OGG1 is a DNA glycosylase enzyme that, in humans, is encoded by the OGG1 gene. It is a DNA repair enzyme involved in base excision repair. It is found in bacterial, archaeal and eukaryotic species. Also known as HMMH, MUTM, OGH1, HOGG1. Cytogenetic Location: The OGG1 gene is located on the short (p) arm of chromosome 3 at position 26.2. (3p26.2) More precisely, the OGG1 gene is located from base pair 9,791,627 to base pair 9,808,352 on chromosome 3. Function: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. OGG1 is a bifunctional glycosylase, as it is able to cleave the glycosidic bond of the mutagenic lesion and also cause a strand break in the DNA backbone. The action of this enzyme includes lyase activity for chain cleavage. Significance: The majority of DNA damage is caused by ubiquitous reactive oxygen species(ROS). ROS are chemically very active molecules created as byproducts of respiration. When DNA meets reactive oxygen species, one of the most common reactions is the transformation of the DNA base guanine into a molecule called 8-oxoguanine, which can produce mutations in genes. To protect the integrity of the genetic code, cells remove 8-oxoguanine from their DNA with a repair enzyme called OGG1. OGG1 does its job by attaching to a damaged base, cutting it free from the DNA molecule, and then releasing it. Boldogh and his collaborators proposed the hypothesis that instead of the accumulation of damaged guanine in DNA causing ill effects, what is significant, is the release of a DNA-repair byproduct that somehow activates processes that shorten the lifespan of cells. In experimenting this ,they found their key byproduct was being produced just after this repair process was completed. Analyzing test-tube, cell-culture and mouse experimental data, they realized that immediately after being released by OGG1, 8-oxoguanine reunites with the repair enzyme, attaching at a bonding site different from the one used previously. And the resulting 8-oxoguanine-OGG1 complex, they found, has the ability to activate the powerful Ras signaling pathways, some of the most important biochemical networks in the cell. Ras family proteins are involved in almost every cell function like metabolism, activation of genes, growth signals, inflammation signals, apoptosis. Because it activates Ras pathway, the release of 8-oxoguanine in DNA base repair could be a master regulator of many basic processes. Learning to control this "Master regulator," could result in profound consequences for biomedical science and human health. The ability to regulate 8-oxoguanine excision may give us the ability to prevent the inflammation that is key to a number of chronic diseases — arthritis, atherosclerosis, Alzheimer's and others. It is believed that it may even enable us to extend lifespan, or at least healthy lifespan, which would be a very big achievement. Possibilities like that make us believe that this discovery is going to be very significant.Advancement : It has been found that OGG1 tagging has been successful by researchers in Harvard University .
Source : IAOMP Herald 2013; April-May :Vol 3 :issue 2 .